FZD1 Antibody, Biotin conjugated

Size : 50 µg Clone Number: Aliases: Chfz-1 antibody; Dfrizzled-1 antibody; DKFZp564G072 antibody; FLJ95923 antibody; Frizzled 1 antibody; Frizzled homolog 1 (Drosophila) antibody; Frizzled homolog 1 antibody; Frizzled-1 antibody; Fz receptor 1 antibody; Fz-1 antibody; Fz1 antibody; FZD1 antibody; FZD1_HUMAN antibody; FzE1 antibody; hFz1 antibody; Rfz1 antibody; Wnt receptor antibody; Xfrizzled-1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9UP38 Immunogen: Recombinant Human Frizzled-1 protein (73-322AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Biotin Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: FZD1 Research Areas: Cancer; Signal transduction; Stem cells