FZD7 Antibody

Size : 50 µL Clone Number: Aliases: Frizzled 7; seven transmembrane spanning receptor antibody; frizzled class receptor 7 antibody; Frizzled drosophila homolog of 7 antibody; Frizzled family receptor 7 antibody; Frizzled homolog 7 antibody; Frizzled-7 antibody; Frizzled7 antibody; Fz 7 antibody; Fz-7 antibody; Fz7 antibody; FZD 7 antibody; FZD7 antibody; FZD7_HUMAN antibody; FzE 3 antibody; FzE3 antibody; hFz 7 antibody; hFz7 antibody; Homolog of Drosophila Frizzled 7 antibody; OTTHUMP00000163742 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O75084 Immunogen: Recombinant Human Frizzled-7 protein (161-239AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 1000-1: 5000, IHC: 1: 200-1: 500 Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: FZD7 Research Areas: Cancer; Signal transduction; Stem cells